Pharyngula

Wednesday, January 11, 2006

Cyclopia

Apostropher mentions that some people find this picture of a one-eyed kitty unbelievable. Should I mention one of my little hobbies?

{if "

I do some work on holoprosencephaly. That kind of cyclopia is fairly common, and here are a few "!=""}

I do some work on holoprosencephaly. That kind of cyclopia is fairly common, and here are a few pictures to back that up.

image

At the top left is a zebrafish larva with ethanol-induced cyclopia, and a control below it. Top right are some sheep skulls—the top one is a case of natural holoprosencephaly, induced by a teratogen found in plants of the genus Veratrum (Mama Sheep ate some bad weeds during her pregnancy). The bottom picture is a row of rabbit pups that were intentionally exposed to that same teratogen, and all were born with that weird one-eyed look.

I've got a set of procedures that allow me to generate one-eyed fish at will. The agents responsible seem to muck up signal transduction at the midline in early development; my particular interest is in tracking down the patterns of cell death and aberrant cell migrations that produce the final phenotype. So, the one-eyed baby animal is a common sight around here, and the kitten is actually a rather uninteresting example: I like animals where I have access to the whole process of eye and face development in a petri dish, without have to chop into a bloody messy uterus to see it.

Oh, and my one-eyed fish don't make it to adulthood. Changes to the facial midline disrupt primary blood flow rather catastrophically, and they only last a week to ten days, with diminished circulation in the body and an unfortunately inflating heart and pericardium—their hearts actually explode.

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Trackback url: http://tangledbank.net/index/trackback/3705/

Comments:
{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57496: — 01/11  at  01:26 PM {/if}
{if FALSE} {/if} {if TRUE} Oooo, I wouldn't tell the animal rights folks!! {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57498: — 01/11  at  01:32 PM {/if}
{if FALSE} {/if} {if TRUE} Kittens are generally born with their eyes shut. Why is this one's eye open if it's only one day old? {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57501: Mrs Tilton — 01/11  at  01:35 PM {/if}
{if FALSE} {/if} {if TRUE} And some people say there is no such thing as synchronicity. There I was, reading a Christmas present, Sean Carroll's Endless Forms Most Beautiful -- thanks, O Best Sister-in-Law in the World! -- and saw the piccie of the cyclops lamb on page 39. And that very same day I follow Norbizness's link to the cyclopokitty and read that people were all sceptical about it, and I was like, oh, so you've never seen pregnant mama cats eating V. californicum before???!!!

Or maybe the cyclopokitties' mamas eat sheep who've eaten the weed; or maybe they are the offspring of Uranus and Gaia. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57504: coturnix — 01/11  at  01:54 PM {/if}
{if FALSE} {/if} {if TRUE} My old vet school had a large museum of preserved terratologies and cyclopsy was the most common one, found in pretty much all domestic animals. Really cool! {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57505: Caspar — 01/11  at  01:56 PM {/if}
{if FALSE} {/if} {if TRUE} how about a cat or fish with three eyes? now that would be something. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57506: — 01/11  at  01:56 PM {/if}
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I've got a set of procedures that allow me to generate one-eyed fish at will.


This is the greatest sentance ever written in the English language. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57509: — 01/11  at  02:03 PM {/if}
{if FALSE} {/if} {if TRUE} PZ, does this condition invariably lead to death within hours or days for mammalian infants, as well? (Could this kitten possibly have survived for any length of time, in other words?). {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57515: Evan Murdock — 01/11  at  02:22 PM {/if}
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Kittens are generally born with their eyes shut. Why is this one's eye open if it's only one day old?


from snopes.com:

Eyelids are also generally absent in such births, which explains why the eye of the one-day-old kitten pictured above is open even though cats are usually born with their eyes shut and remain in that condition for the first week or two of their lives.


Weird. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57516: flyingcamel — 01/11  at  02:23 PM {/if}
{if FALSE} {/if} {if TRUE} Frumious- the condition generally results in the eyelid being absent, so the kitten's eye would be permanently open. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57517: coturnix — 01/11  at  02:33 PM {/if}
{if FALSE} {/if} {if TRUE} Is this a two-day-premature Friday Cat Blogging? Modulator is going to love it for the Friday Ark, too, I bet... {/if}

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{if TRUE} Trackback: Poor Cyclops Kitty :( :( Tracked on: I Love Everything (203.123.80.12) at 2006 01 11 14:53:47 {/if} {if FALSE} {if FALSE} {/if} #: — {comment_date format='%m/%d'}  at  {comment_date format='%h:%i %A'} {/if}
{if TRUE} More: Apostropher mentions that some people find this picture of a one-eyed kitty unbelievable. Should I mention one of my little hobbies? I do some work on holoprosencephaly. That kind of cyclopia is fairly common, and here are a few pictures to bac... {/if} {if FALSE} {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57520: — 01/11  at  03:14 PM {/if}
{if FALSE} {/if} {if TRUE} Show this picture to all those Intelligent Design idjits...how would Dembski et al. explain away developmental mistakes like this poor little kitty?

"If it turns out that there is a God, I don't think that he's evil. But the worst that you can say about him is that basically he's an underachiever."--Woody Allen {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57525: — 01/11  at  03:49 PM {/if}
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PZ: I've got a set of procedures that allow me to generate one-eyed fish at will.


Epat: This is the greatest sentance ever written in the English language.

It would go well with: "I have a large supply of fissionable materials" (from SF short story Who Can Replace a Man) {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57526: Mrs Tilton — 01/11  at  03:52 PM {/if}
{if FALSE} {/if} {if TRUE} how about a cat or fish with three eyes? now that would be something.

You've never visited Springfield, I take it.

Can't help you with the cat, though. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57527: — 01/11  at  03:53 PM {/if}
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PZ: I've got a set of procedures that allow me to generate one-eyed fish at will.


Epat: This is the greatest sentance ever written in the English language.

It would go well with: "I have a large supply of fissionable materials" (from SF short story Who Can Replace a Man IIRC) {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57530: — 01/11  at  04:09 PM {/if}
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Show this picture to all those Intelligent Design idjits...how would Dembski et al. explain away developmental mistakes like this poor little kitty?
Well, you know, intelligent people make mistakes, so why not the designer? An omnipotent designer wouldn't make that mistake, but the idjits aren't talking about an omnipotent designer...at least not some of the time.

Nope, the IDer is a screw-up just like you and me. You know, in his image and all that jazz... {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57532: — 01/11  at  04:15 PM {/if}
{if FALSE} {/if} {if TRUE} God doesn't micro-manage his creation, he gave it all to us humans to manage from the start. This abnormality and all others reflect the managers more than the creator! {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57533: — 01/11  at  04:27 PM {/if}
{if FALSE} {/if} {if TRUE} Nope, the IDer is a screw-up just like you and me. You know, in his image and all that jazz...

So, can we start calling ID "Incompetent Design?"

I'm sure someone's done this, but it still sounds good to me.

CS {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57537: fish — 01/11  at  04:49 PM {/if}
{if FALSE} {/if} {if TRUE} How about a cat or a fish with three eyes?

I can show you a fruitfly with extra eyes:



Turns out it is not so hard to make either... {/if}

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{if TRUE} Trackback: Threescore Times Ten Million Years Ago, Our Forefathers Tracked on: Frothing at the Mouth (70.106.123.194) at 2006 01 11 16:50:57 {/if} {if FALSE} {if FALSE} {/if} #: — {comment_date format='%m/%d'}  at  {comment_date format='%h:%i %A'} {/if}
{if TRUE} Holy fuck, there's an Ediacaran chordate! More on the Panda's Thumb, including: [Y]ou can see grooves that record the record the muscle bands [...] there are now 18 of these fossils described, preserved in every possible orientation, so they know... {/if} {if FALSE} {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57542: — 01/11  at  05:02 PM {/if}
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God doesn't micro-manage his creation, he gave it all to us humans to manage from the start. This abnormality and all others reflect the managers more than the creator!
Wait. So it's up to us to oversee the reproduction of, what, every organism on the planet? Why didn't the designer tell us? We could've gotten a jumpstart on this biology thing millenia ago. But I guess there's been a communication breakdown from the start... {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57545: — 01/11  at  05:09 PM {/if}
{if FALSE} {/if} {if TRUE} This post has been a treasure chest of great sentences. The one-eyed fissionable material, of course. And my current fave, "Holy fuck, there's an Ediacaran chordate!"

You folks make my day. Oh, and parting thought--the person who posted the cyclopokitty pic called it adorable? Not even. I haven't seen a...nah. I won't cheapen this fine site. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57549: Jon D. Moulton — 01/11  at  05:44 PM {/if}
{if FALSE} {/if} {if TRUE} A Morpholino oligo can induce a nifty phenocopy of the zebrafish one-eyed pinhead (oep) mutation. Since the oligo can knock down maternal transcript as well as zygotic transcript, you can get a more extreme phenotype than a natural mutant, with functional its maternal transcript, can produce. For an image, see slide # 32 in the PowerPoint presentation available at:
http://www.gene-tools.com/files/China2005NoAnimation.ppt {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57551: — 01/11  at  06:06 PM {/if}
{if FALSE} {/if} {if TRUE} If this is the best God can do, I'm not impressed.
-- George Carlin, Napalm & Silly Putty (2001) †† {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57554: Martin Wagner — 01/11  at  06:28 PM {/if}
{if FALSE} {/if} {if TRUE} Poor little fella. Got a real lousy hand from the bottom of the DNA deck. Oh well, another nail in the ID coffin...no wait, it's not! Apparently it's all our fault! Gee, thanks for clearing that up, Wiselder! {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57560: Keith Douglas — 01/11  at  07:15 PM {/if}
{if FALSE} {/if} {if TRUE} What a pitiful, sad, creature. I am glad that some people (like PZ) are working on understanding such sports of nature, though. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57564: — 01/11  at  08:26 PM {/if}
{if FALSE} {/if} {if TRUE} I dunno, the sentence that really grabbed me was:
Should I mention one of my little hobbies?

That one had sinister chuckle all over it! {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57565: — 01/11  at  08:54 PM {/if}
{if FALSE} {/if} {if TRUE} To answer Polyphemus question:
Cyclopia is a well-recognized human congenital condition, and the poor infants are either stillborn or live only a few hours or days after birth. This is due to the usual host of associated anomalies such as a unilobate brain (holoprosencephaly), malformed heart, abnormal blood circulation. They have a characteristic appearance, with a normal appearing body, but a face with a single midline fused orbit and a variably fused eye, and a proboscis (non-functioning nose) ABOVE the eye. They are doubtless the source of the legendary Cyclops of the ancient Greeks. {/if}

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{if TRUE} Trackback: Cyclops-Kitty? Qu'est-ce que c'est? Tracked on: PhaWRONGula (72.9.234.70) at 2006 01 11 21:05:33 {/if} {if FALSE} {if FALSE} {/if} #: — {comment_date format='%m/%d'}  at  {comment_date format='%h:%i %A'} {/if}
{if TRUE} ...It was a one-eyed, soon died, google-pimpin' puddy-picture, One-eyed, bona fide! blog-bloatin' puddy-picture, One-eyed, worldwide web-invadin' puddy-picture... {/if} {if FALSE} {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57579: — 01/11  at  10:30 PM {/if}
{if FALSE} {/if} {if TRUE} Here's a dishy piece of utterly speculative gossip for you all: Tom Cruise might have holoprosencephaly! A neurologist muses aloud: http://www.metafilter.com/mefi/45654#1066483

Midline incisor, family history of retardation, dyslexia, small stature, history of stillborn babies... the signs are there. And Tom recently bought Katie an ultrasound machine. To monitor facial development of the embryo, perhaps?

If true, I think it's wonderous. Somehow, a little mutant troll, stunted both genetically and culturally, has become America's sweetheart. It's like a fairy tale. {/if}

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{if TRUE} Trackback: Коте-мутант Tracked on: DaggerRant (207.7.108.235) at 2006 01 12 03:05:56 {/if} {if FALSE} {if FALSE} {/if} #: — {comment_date format='%m/%d'}  at  {comment_date format='%h:%i %A'} {/if}
{if TRUE} По време на дневната блог обиколка се натъкнах на това: ... {/if} {if FALSE} {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57598: Bryan Trim — 01/12  at  05:51 AM {/if}
{if FALSE} {/if} {if TRUE} When I was stationed at Fort Sam Houston, TX I worked at Brooke Army Medical center. One of the strange "details" i got stuck with was going down to the histopathology department and getting rid of about a years worth of old anatomical pathology specimens. Mainly stuff like leftovers from autopsies. However, there was an entire room filled with preserved specimens, such as conjoined fetuses ect. The oddest one had four legs, two arms,and a big old head that had two big lobes in the back, and a weird mashed together face. There were other specimens of note, but no cyclopeans...... {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57602: MBains — 01/12  at  07:35 AM {/if}
{if FALSE} {/if} {if TRUE} Two from Mrs Tilton:
Or maybe the cyclopokitties' mamas eat sheep who've eaten the weed;

Oh yah! We can all benefit from that warning! {-;


or maybe they are the offspring of Uranus and Gaia.

I thought those were called butt-puppies??? er... yikes!

Either way, I'm taking No Wallpaper from this post. LOL! {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57608: — 01/12  at  09:20 AM {/if}
{if FALSE} {/if} {if TRUE} PZ Myers Perhaps you should have mentionned that holoprosencephaly happens (not on purpose, though) in humans. Aha and now the horde of IDiots will tax you of non scientific propaganda because it does not fit with the view of God creating us ressembling his image... {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57610: — 01/12  at  09:41 AM {/if}
{if FALSE} {/if} {if TRUE}
PZ Myers Perhaps you should have mentionned that holoprosencephaly happens (not on purpose, though) in humans. Aha and now the horde of IDiots will tax you of non scientific propaganda because it does not fit with the view of God creating us ressembling his image...

Who says JHVH doesn't have one big ol' lidless eye in the middle of his/her forehead?

That'd be scary as shit. Wouldn't you be intimated into compliance by that?

After all, look at all those arms Vishnu has... {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57614: — 01/12  at  10:04 AM {/if}
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Who says JHVH doesn't have one big ol' lidless eye in the middle of his/her forehead?

That'd be scary as shit. Wouldn't you be intimated into compliance by that?


A burning lidless eye? Oooh! {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57621: — 01/12  at  10:58 AM {/if}
{if FALSE} {/if} {if TRUE} In the kitten, how is the brain development affected? Is it a single hemisphere in front, and split further back? Does the optic nerve split on the way back to the brain, or is it connected at all?

I'm curious, but - ick! {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57622: — 01/12  at  11:11 AM {/if}
{if FALSE} {/if} {if TRUE} When I was a kid, my father was the curator of a small museum with specimens of nature's jokes. There were several (human) cyclopeans amongst them, as well as fetuses with their organs on the outside, two-headed animals and other interesting things (and a skeleton by the door whose hand you could shake). The interior of the museum was still the same as it had been in the 19th century, when the collection was first started.

My sister and I loved that museum. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57624: Leftist Boddhisatva — 01/12  at  11:53 AM {/if}
{if FALSE} {/if} {if TRUE} PZ, you need to link to your new site (which looks nice BTW)

Best {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57639: — 01/12  at  03:06 PM {/if}
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PZ: I've got a set of procedures that allow me to generate one-eyed fish at will.

Epat: This is the greatest sentance ever written in the English language.

It would go well with: "I have a large supply of fissionable materials" (from SF short story Who Can Replace a Man)

I'm thinking it could be the first lyric of a Joe Walsh song. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57662: — 01/13  at  09:04 AM {/if}
{if FALSE} {/if} {if TRUE} The book:
http://www.amazon.com/gp/product/0142004820/sr=1-1/qid=1137164380/ref=pd_bbs_1/104-1681113-4781561?%5Fencoding=UTF8
has a good discussion of various freakishly weird birth conditions and genetic defects in humans, including cyclopia, with accompanying pictures. It's for a non-science audience. I found it enlightening. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57694: Alethea — 01/25  at  03:34 AM {/if}
{if FALSE} {/if} {if TRUE} I'm curious about the blood-flow issue. Mammalian cyclops don't have this problem. Is the aortic arch misshapen in the zebrafish, too?
Also, do you get to pick the "submit the word you see below" list? because it's awfully embryological this time. {/if}

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{if FALSE} Trackback: Cyclopia Tracked on: () at {trackback_date format="%Y %m %d %H:%i:%s"} {/if} {if TRUE} {if FALSE} {/if} #57701: Wil Nusser — 02/01  at  07:17 AM {/if}
{if FALSE} {/if} {if TRUE}

So, can we start calling ID "Incompetent Design?"

I'm sure someone's done this, but it still sounds good to me.

CS -- This has been done, complete with a song. Find it here:

http://www.seedmagazine.com/news/2005/11/the_other_id.php

-- Wil {/if}

{if FALSE} {/if} {if signature} {/if}


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