Cyclopia
Apostropher mentions that some people find this picture of a one-eyed kitty unbelievable. Should I mention one of my little hobbies?
{if "I do some work on holoprosencephaly. That kind of cyclopia is fairly common, and here are a few "!=""}
I do some work on holoprosencephaly. That kind of cyclopia is fairly common, and here are a few pictures to back that up.
At the top left is a zebrafish larva with ethanol-induced cyclopia, and a control below it. Top right are some sheep skulls—the top one is a case of natural holoprosencephaly, induced by a teratogen found in plants of the genus Veratrum (Mama Sheep ate some bad weeds during her pregnancy). The bottom picture is a row of rabbit pups that were intentionally exposed to that same teratogen, and all were born with that weird one-eyed look.
I've got a set of procedures that allow me to generate one-eyed fish at will. The agents responsible seem to muck up signal transduction at the midline in early development; my particular interest is in tracking down the patterns of cell death and aberrant cell migrations that produce the final phenotype. So, the one-eyed baby animal is a common sight around here, and the kitten is actually a rather uninteresting example: I like animals where I have access to the whole process of eye and face development in a petri dish, without have to chop into a bloody messy uterus to see it.
Oh, and my one-eyed fish don't make it to adulthood. Changes to the facial midline disrupt primary blood flow rather catastrophically, and they only last a week to ten days, with diminished circulation in the body and an unfortunately inflating heart and pericardium—their hearts actually explode.
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{if FALSE} {/if} {if TRUE} Oooo, I wouldn't tell the animal rights folks!! {/if}
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